The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2026
Filed:
Jul. 19, 2021
Shanghai Shengping Medical Equipment Co., Ltd., Shanghai, CN;
Vastpro (Zhejiang) Technology Development Co., Ltd., Shanghai, CN;
Zhejiang Boxiao Biopharmaceutical Co., Ltd., Hangzhou, CN;
Guangyin Wang, Shanghai, CN;
Xiaoming Li, Shanghai, CN;
Chengxi Wang, Shanghai, CN;
Ping Huang, Shanghai, CN;
Hua Bai, Shanghai, CN;
Liang Lai, Shanghai, CN;
Peng Guo, Shanghai, CN;
Biao Jiang, Shanghai, CN;
Wenfeng Zhu, Shanghai, CN;
Shanghai Shengping Medical Equipment Co., Ltd., Shanghai, CN;
VastPro (Zhejiang) Pharmaceutical Co., Ltd., Shanghai, CN;
Zhejiang Boxiao Biopharmaceutical Co., Ltd., Zhejiang, CN;
Abstract
The present invention provides a method for biological and chemical synthesis of tetrodotoxin, specifically comprising the following steps: using cheap and easily available benzyl acetate as a raw material, and performing biological fermentation to obtain an optically pure intermediate ((5S, 6R)-5, 6-dihydroxycyclohexa-1, 3-dienyl) methyl acetate (formula I); and performing a series of chemical conversions on the intermediate to finally obtain tetrodotoxin at a purity of 95% or more without purifying the product. The present invention has the potential of large-scale production, and is an excellent alternative to the existing extraction method from a pufferfish.