The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2026
Filed:
Oct. 25, 2024
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Gerald R. Crabtree, Stanford, CA (US);
Nathanael Gray, Stanford, CA (US);
Sai Gourisankar, Stanford, CA (US);
Andrey Krokhotin, Stanford, CA (US);
Wenzhi Ji, Stanford, CA (US);
Tinghu Zhang, Stanford, CA (US);
Samuel H. Kim, Stanford, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
Methods of regulating expression of a target gene in a cell are provided. Aspects of the methods contacting the cell with a compound having a first moiety covalently linked to a second moiety, wherein: (i) the first moiety exhibits specific binding to a first endogenous protein; (ii) the second moiety exhibits specific binding to a second endogenous protein distinct from the first endogenous protein; and (iii) upon contacting the cell, the first endogenous protein and the second endogenous protein are spatially complexed to each other via the compound to yield a gain-of-function in the cell and thereby activate a process not normally controlled by either of the first and second endogenous proteins. Embodiments of the methods provide one or more beneficial features, including but not limited to: utilization of less than about 50% of an amount of the second endogenous protein present in the cell; mediation of the gain-of-function with an EC50 of less than about 1 micromolar; modulation of expression of the target gene in less than or equal to about 16 hours; etc. Also provided are compositions that find use in practicing methods of the disclosure.