The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2026
Filed:
Dec. 20, 2019
Agency for Science, Technology and Research, Singapore, SG;
National University Hospital (Singapore) Pte Ltd, Singapore, SG;
National University of Singapore, Singapore, SG;
Patrick Tan, Singapore, SG;
Raghav Sundar, Singapore, SG;
Kie Kyon Huang, Singapore, SG;
Aditi Qamra, Singapore, SG;
Jonathan Goke, Singapore, SG;
Deniz Demircioglu, Singapore, SG;
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, Sinagapore, SG;
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD, Singapore, SG;
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, SG;
Abstract
The present invention relates to a method of identifying a patient suffering from cancer as benefiting or not benefiting from immune checkpoint inhibition therapy comprising the steps of measuring an expression level of one or more preselected markers in a cancerous biological sample obtained from the patient, identifying a differentially expressed alternative promoter based on the expression level of the one or more preselected markers, calculating an alternative promoter usage score and identifying the patient as benefiting or not benefiting from immune checkpoint inhibition therapy using the alternative promoter usage score. The present invention also relates to a biomarker for excluding a patient suffering from cancer from immune checkpoint inhibition therapy.