The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2026

Filed:

Jun. 24, 2020
Applicant:

Ucb Biopharma Srl, Brussels, BE;

Inventors:

Shuyu Chu, Slough, GB;

Helen Tracey Horsley, Slough, GB;

James Thomas Reuberson, Slough, GB;

Richard David Taylor, Slough, GB;

Zhaoning Zhu, Slough, GB;

Rose Elizabeth Chappell, Abingdon, GB;

Gregory William Haslett, Slough, GB;

Adam Peter Smalley, Slough, GB;

Nathaniel Julius Thomas Monck, Abingdon, GB;

Gareth Neil Brace, Abingdon, GB;

Prafulkumar Tulshibhai Chovatia, Abingdon, GB;

Assignee:

UCB Biopharma SRL, Brussels, BE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 31/4245 (2006.01); A61K 31/4353 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/4245 (2013.01); A61K 31/4353 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01);
Abstract

A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C—Ror N; B represents C—Ror N; D represents C—Ror N; E represents C—Ror N; Z represents —CH(R)N(H)CHR, —CH(R)N(H)S(O)R, —C(═CRR)N(H)C(O)R, —CH(R)R, —CH(R)N(H)Ror —CH(R)C(O)N(H)R; Rrepresents hydrogen or Calkyl.


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