The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2026
Filed:
Dec. 10, 2021
Bolt Biotherapeutics, Inc., Redwood City, CA (US);
Shelley Erin Ackerman, Redwood City, CA (US);
Michael N. Alonso, Redwood City, CA (US);
Romas Kudirka, Redwood City, CA (US);
Arthur Lee, Redwood City, CA (US);
Brian Safina, Redwood City, CA (US);
Matthew Zhou, Redwood City, CA (US);
BOLT BIOTHERAPEUTICS, INC., Redwood City, CA (US);
Abstract
The invention provides immunoconjugates of Formula I comprising an anti-HER2 antibody linked by conjugation to one or more 8-Het-2-aminobenzazepine derivatives. The invention also provides 8-Het-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.