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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12678464 B1

PDFFull Text
Date of Patent:
Jul. 14, 2026

Filed:

Mar. 10, 2022

Methods for stem cell transplantation

Applicant:

The Uab Research Foundation, Birmingham, AL (US);

Inventors:

Lawrence S Lamb, Birmingham, AL (US);

Shin Mineishi, Vestavia Hills, AL (US);

Ayman Saad, Hoover, AL (US);

Assignee:

THE UAB RESEARCH FOUNDATION, Birmingham, AL (US);

Attorneys:

Nicholas J. Landau

Maynard Nexsen PC

Primary Examiner:

Michail A Belyavskyi

Int. Cl.
CPC ...
A61K 35/28 (2015.01); A61K 31/436 (2006.01); A61K 31/5377 (2006.01); A61K 31/675 (2006.01); A61K 35/14 (2015.01); A61K 38/19 (2006.01); A61K 40/11 (2025.01); A61K 40/22 (2025.01); A61K 40/41 (2025.01); A61P 37/06 (2006.01); C12N 5/00 (2006.01); C12N 5/0783 (2010.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 31/436 (2013.01); A61K 31/5377 (2013.01); A61K 31/675 (2013.01); A61K 35/14 (2013.01); A61K 38/193 (2013.01); A61K 40/11 (2025.01); A61K 40/22 (2025.01); A61K 40/418 (2025.01); A61P 37/06 (2018.01); C12N 5/0087 (2013.01); C12N 5/0636 (2013.01); A61K 45/06 (2013.01); A61K 2239/38 (2023.05);
Abstract

The present disclosure provides methods of hematopoietic stem cell transplantation (HSCT). In particular, the present disclosure provides a method of HSCT using a combination of an in-vivo T-cell depletion method, with an ex-vivo method of γδ T cell expansion and as T cell depletion. The in-vivo T-cell depletion method depletes (in-vivo) the alloreactive T cells that would otherwise increase the risk of GvHD.

Find Patent Forward Citations

Lamb, Lawrence. (2026). Methods for stem cell transplantation (U.S. Patent No. 12678464). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12678464

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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