The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2026

Filed:

Aug. 12, 2021
Applicant:

Trustees of Tufts College, Medford, MA (US);

Inventors:

David L. Kaplan, Medford, MA (US);

John Yuen, Medford, MA (US);

Natalie R. Rubio, Medford, MA (US);

Assignee:

Trustees of Tufts College, Medford, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A23L 13/00 (2016.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12M 3/00 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A23L 13/00 (2016.08); C12M 21/08 (2013.01); C12M 23/58 (2013.01); C12M 25/14 (2013.01); C12M 29/16 (2013.01); C12N 5/0068 (2013.01); C12N 5/0658 (2013.01); C12N 5/0697 (2013.01); C12N 2513/00 (2013.01); C12N 2533/50 (2013.01);
Abstract

The present disclosure relates to cultured tissue, methods for production of the cultured tissue, and a bioreactor system for production of the cultured tissue. In some embodiments, the production of the cultured tissue may involve, at a first bioreactor, feeding a fiber scaffold into a chamber containing culture media, seeding the chamber with precursor cells, and allowing the precursor cells to proliferate and differentiate on a surface of the fiber scaffold. At downstream bioreactors, the production of the cultured tissue may further involve twisting a plurality of the cell-laden fibers to provide a cell-laden yarn, and weaving or knitting the cell-laden yarn into a three-dimensional (3D) structure. In some embodiments, the cultured tissue may be whole muscle cultured meat composed of muscle cell-laden fibers and fat cell-laden fibers. The whole muscle cultured meat may have a structural organization and hierarchy that mimics natural skeletal muscle tissue.


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