The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2026
Filed:
Jun. 05, 2020
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Ospedale San Raffaele S.r.l., Milan, IT;
Fondazione Telethon, Rome, IT;
Rosa Bacchetta, Menlo Park, CA (US);
Maria Grazia Roncarolo, Menlo Park, CA (US);
Yohei Sato, Palo Alto, CA (US);
Luigi Naldini, Milan, IT;
Laura Passerini, Milan, IT;
Abstract
Engineered Treg-like cells, CD4T cells, and their use in cellular therapy to promote immune tolerance are disclosed. In particular, CD4T cells are produced by transduction of CD4T cells with a lentiviral vector expressing FOXP3 under the control of a constitutive promoter. Transduced cells express FOXP3 at high and persistent levels and acquire immune suppressive characteristics resembling naturally occurring Treg cells.