The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2026

Filed:

Dec. 29, 2021
Applicant:

Shanghai Abelzeta Ltd., Shanghai, CN;

Inventors:

Jia Li, Shanghai, CN;

Jiyan Hou, Shanghai, CN;

Zizhen Gong, Shanghai, CN;

Yijie Qu, Shanghai, CN;

Shichao Qin, Shanghai, CN;

Shenchen Wang, Shanghai, CN;

Wangqin Shu, Shanghai, CN;

Junfeng Wu, Shanghai, CN;

Fei Wang, Shanghai, CN;

Li Zhang, Shanghai, CN;

Assignee:

Shanghai AbelZeta Ltd., Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/078 (2010.01); A61K 40/11 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0634 (2013.01); A61K 40/11 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2018.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/2321 (2013.01); C12N 2501/73 (2013.01); C12N 2501/734 (2013.01);
Abstract

Provided are methods for expanding tumor-infiltrating lymphocytes (TILs), which include co-culturing an initial cell population containing TILs with first feeder cells to obtain a first expanded cell population; and then co-culturing the first expanded cell population with second feeder cells to obtain an expanded TIL population. The methods can quickly produce a large number of TILs from a small tumor sample.


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