The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2026
Filed:
Dec. 23, 2022
The Katholieke Universiteit Leuven, Vlaams-Brabant Leuven, BE;
Springworks Therapeutics, Inc., Stamford, CT (US);
Vib Vzw, Ghent, BE;
Bart Vanderhoydonck, Diest, BE;
Arnaud Marchand, Bierbeek, BE;
Aurélie Candi, Werchter, BE;
Matthias Versele, Kessel-Lo, BE;
Spring Works Therapeutics, Inc., Stamford, CT (US);
THE KATHOLIEKE UNIVERSITEIT LEUVEN, Vlaams-Brabant Leuven, BE;
VIB vzw, Ghent, BE;
Abstract
The present disclosure relates to spiro-fused tetrahydroquinazoline compounds, to the compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of diseases comprising the use of the compounds. The present disclosure furthermore relates to pharmaceutical compositions or combination preparations of the compounds as well as to compositions or preparations for use as a medicine, more preferably for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to processes for the preparation of compounds.