Precursor compound of hexahydro-beta-acid component compound, feed composition and use thereof

Abstract

The present invention discloses the prodrugs of hexahydro-β-acid compounds, feed composition and use thereof, and a prodrug of hexahydro-β-acid compound of formula (I), or solvates thereof, or feed-acceptable salts thereof, wherein Ris selected from a substituted or unsubstituted C-Calkyl, and each of Rand Ris independently selected from H and a linear or branched C-Ccarbonyl, wherein the C-Ccarbonyl is substituted or unsubstituted. Disclosed herein is that the prodrug of a hexahydro-β-acid compound from esterification by aliphatic acid exhibits excellent stability at high temperature to overcome the problem resulting from the degradation of hexahydro-β-acid compound in a high-temperature pelleting process. Furthermore, disclosed herein is that, both propionate and butyrate, the prodrugs of a hexahydro-β-acid compound from esterification by aliphatic acid, and feed-acceptable salt thereof and solvate thereof, are stable in high-temperature feed processing and achieve effects substantially equal to the hexahydro-β-acid compound in farm breeding.