The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2026
Filed:
Mar. 06, 2023
Zhejiang Wynca Chemical Industry Group Co., Ltd, Zhejiang, CN;
Zhejiang University, Zhejiang, CN;
Shuguang Zhou, Hangzhou, CN;
Lirong Yang, Hangzhou, CN;
Long Qin, Hangzhou, CN;
Haisheng Zhou, Hangzhou, CN;
Shenluan Yu, Hangzhou, CN;
Jianping Wu, Hangzhou, CN;
Linlin Wang, Hangzhou, CN;
Bo Zhan, Hangzhou, CN;
Ping Wang, Hangzhou, CN;
ZHEJIANG WYNCA CHEMICAL INDUSTRY GROUP CO., LTD, Hangzhou, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
Abstract
The present invention provides a method for preparing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, comprising the following steps: a) mixing acryloyl chloride, a first solvent, a polymerization inhibitor, a catalyst and potassium ferrocyanide, performing a substitution reaction, and performing distillation under reduced pressure to obtain an acryloyl cyanide intermediate; b) mixing the acryloyl cyanide intermediate obtained in step a) with hydrochloric acid and a polymerization inhibitor, performing a hydrolysis reaction, and then performing purification treatment to obtain crude 2-carbonyl-3-butenoic acid; c) mixing the crude 2-carbonyl-3-butenoic acid obtained in step b) with a second solvent and methyldichlorophosphine, and performing an addition reaction to obtain a solution containing diacyl chloride; d) mixing the solution containing diacyl chloride obtained in step c) with water, performing a hydrolysis reaction, and performing purification to obtain 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid. The preparation method provided by the present invention has simple process, mild conditions, good controllability, low cost and high yield.