The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2026
Filed:
Sep. 15, 2021
The Johns Hopkins University, Baltimore, MD (US);
Lieber Institute, Inc., Baltimore, MD (US);
Hester Hui Liu, Cockeysville, MD (US);
James C. Barrow, Arnold, MD (US);
Marikki K. Laiho, Kauniainen, FI;
Rajesh Kumar Nv, Baltimore, MD (US);
Pablo De Leon, Baltimore, MD (US);
Tony Dorado, Baltimore, MD (US);
Asma Begum, Baltimore, MD (US);
Wenjun Fan, Baltimore, MD (US);
Gregory Stachelek, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Lieber Institute, Inc., Baltimore, MD (US);
Abstract
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit RNA polymerase I (Pol I). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) Pol I activity contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.