The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2026

Filed:

Jun. 03, 2022
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Elizabeth Mary Beck, Abingdon, GB;

Robert Pullin, Oxford, GB;

Gorka Etxebarria Jardi, Badalona, ES;

Dean Stamos, Lexington, MA (US);

Yvonne Schmidt, San Diego, CA (US);

Joseph Pontillo, San Diego, CA (US);

Stephen Andrew Thomson, Durham, NC (US);

David Matthew Shaw, Oxford, GB;

Nadia M. Ahmad, Hayes, GB;

Lidio Marx Carvalho Meireles, San Marcos, CA (US);

Sarah Skerratt, Cambridge, GB;

Sara S. Hadida Ruah, La Jolla, CA (US);

Timothy Donald Neubert, San Diego, CA (US);

Dennis James Hurley, San Marcos, CA (US);

Steven John Durrant, Headington, GB;

Christopher Wray, Berkshire, GB;

Anisa Nizarali Virani, Thatcham, GB;

Kiri North, Oxford, GB;

Bhairavi Galan, Abingdon, GB;

Ronald Marcellus Knegtel, Abingdon, GB;

Ewa Iwona Chudyk, Wantage, GB;

Joanne Louise Pinder, Didcot, GB;

Bruno Artur Sousa, Reading, GB;

Francoise Pierard, Abingdon, GB;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/12 (2006.01); A61K 31/443 (2006.01); A61K 31/501 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/443 (2013.01); A61K 31/501 (2013.01);
Abstract

Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.


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