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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12662469 B1

PDFFull Text
Date of Patent:
Jun. 23, 2026

Filed:

May. 19, 2021

Cyclic ureas

Applicant:

Sironax Ltd, Grand Cayman, KY;

Inventors:

Zhiyuan Zhang, Beijing, CN;

Yaning Su, Beijing, CN;

Jianguang Han, Beijing, CN;

Hanying Ruan, Beijing, CN;

Ying Li, Beijing, CN;

Guozheng Wang, Beijing, CN;

Wendong Liu, Beijing, CN;

Chong Zhang, Beijing, CN;

Leiming Liang, Beijing, CN;

Assignee:

SIRONAX LTD, Grand Cayman, KY;

Attorney:

Troutman Pepper Locke LLP

Primary Examiner:

Andrew D Kosar

Assistant Examiner:

Gillian A Hutter

Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 231/06 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 231/06 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

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