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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12662463 B1

PDFFull Text
Date of Patent:
Jun. 23, 2026

Filed:

Oct. 18, 2023

Method for preparing esomeprazole magnesium trihydrate by crystal transformation

Applicant:

Shandong Analysis and Test Center, Jinan, CN;

Inventors:

Fumin Xue, Jinan, CN;

Shuai Yu, Jinan, CN;

Yuanchang MA, Jinan, CN;

Xujie Gao, Jinan, CN;

Zihao Wang, Jinan, CN;

Yaqi Han, Jinan, CN;

Xingzhu Wang, Jinan, CN;

Assignee:

SHANDONG ANALYSIS AND TEST CENTER, Jinan, CN;

Attorney:

Oliff PLC

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

W. Justin Youngblood

Int. Cl.
CPC ...
C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01);
Abstract

The invention discloses a method for preparing esomeprazole magnesium trihydrate by crystal transformation, and relates to the technical field of pharmaceutical preparations and crystallization. It includes the following steps of preparing an esomeprazole potassium aqueous solution, preparing a magnesium sulfate heptahydrate aqueous solution, a reactive crystallization process to obtain the esomeprazole magnesium tetrahydrate, and filtering the obtained esomeprazole magnesium tetrahydrate to obtain a sphaerocrystal of esomeprazole magnesium trihydrate. The method for preparing esomeprazole magnesium trihydrate by crystal transformation in the present invention is characterized by using the esomeprazole potassium aqueous solution and the magnesium sulfate aqueous solution for ion exchange to obtain the esomeprazole magnesium tetrahydrate. The whole process takes only about 1 hour, which greatly shortens the reaction time, and the obtained esomeprazole magnesium trihydrate has high purity, large particle size, narrow distribution, small angle of repose and good fluidity.

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Xue, Fumin. (2026). Method for preparing esomeprazole magnesium trihydrate by crystal transformation (U.S. Patent No. 12662463). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12662463

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