The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2026
Filed:
Jan. 09, 2023
Nacuity Pharmaceuticals, Inc., Fort Worth, TX (US);
G. Michael Wall, Fort Worth, TX (US);
Doug G. Johnson, Arvada, CO (US);
Anja Rubenstein, Florence, SC (US);
Rodney Tucker, Hartsville, SC (US);
Josh Bolger, Florence, SC (US);
Marcin Jakub Kowalczyk, Mitcham, AU;
Craig Sheehan, Boronia, AU;
Nacuity Pharmaceuticals, Inc., Fort Worth, TX (US);
Abstract
Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R')-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.