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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12661354 B1

PDFFull Text
Date of Patent:
Jun. 23, 2026

Filed:

Feb. 17, 2021

Drg-mdm2-4 for use as a novel mouse double minute 2 (mdm2) inhibitor

Applicants:

Bahcesehir Universitesi, Besiktas/Istanbul, TR;

Istanbul Teknik Universitesi, Istanbul, TR;

Inventors:

Serdar Durdagi, Besiktas/Istanbul, TR;

Timucin Avsar, Besiktas/Istanbul, TR;

Muge Didem Orhan, Besiktas/Istanbul, TR;

Maide Nur Paksoy, Besiktas/Istanbul, TR;

Gulsah Aydin, Besiktas/Istanbul, TR;

Mine Yurtsever, Besiktas/Istanbul, TR;

Assignees:

BAHCESEHIR UNIVERSITESI, Istanbul, TR;

ISTANBUL TEKNIK UNIVERSITESI, Istanbul, TR;

Attorney:

RAPHAEL BELLUM PLLC

Primary Examiner:

Jeffrey H Murray

Assistant Examiner:

Daniel John Burkett

Int. Cl.
CPC ...
A61K 31/501 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/501 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 403/12 (2013.01);
Abstract

The invention relates to compounds according to formula (I) and pharmaceutically acceptable derivatives thereof for use as novel inhibitors of Mouse Double Minute 2 (MDM2) activity by inhibiting interactions between MDM2 and its natural negative regulator, p53. Pharmaceutical compositions containing a compound of Formula (I), or a derivative thereof, including compositions that also contain one or more additional antiproliferative agents, can be used in methods of treating proliferative diseases, including various cancers.

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Quick Actions:

Durdagi, Serdar. (2026). Drg-mdm2-4 for use as a novel mouse double minute 2 (mdm2) inhibitor (U.S. Patent No. 12661354). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12661354

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