The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2026
Filed:
Dec. 27, 2022
Provectus Pharmatech, Inc., Knoxville, TN (US);
University of Tennessee Research Foundation, Memphis, TN (US);
Michio Kurosu, Knoxville, TN (US);
Dominic Rodrigues, Knoxville, TN (US);
Edward V. Pershing, Knoxville, TN (US);
Bruce Horowitz, Knoxville, TN (US);
John Lacey, III, Knoxville, TN (US);
Eric A. Wachter, Oak Ridge, TN (US);
Edward P. Gamson, Highland Park, IL (US);
Provectus Pharmatech, Inc., Knoxville, TN (US);
University of Tennessee Research Foundation, Memphis, TN (US);
Abstract
The present invention contemplates a topical ophthalmic system for treating a Gram-positive bacterially-infected mammalian eye. The system comprises an ophthalmic composition containing a halogenated fluorescein or a pharmaceutically acceptable salt or ester thereof dissolved or dispersed in an aqueous ophthalmic carrier and present in an anti-bacterial keratitis-treating effective concentration of about 0.2 μg/mL to about 50 μg/mL. The ophthalmic composition has a pH value of about 6.5 to about 7.6, a viscosity of about 10 to about 300 cps and an osmolality of about 270 mOsm/kg to about 340 mOsm/kg. The ophthalmic composition is present in a vessel opaque to actinic light. Also contemplated is a method of treating a mammal having a Gram-positive bacterial infection of an eye by administering the ophthalmic composition to the infected eye and maintaining the treated eye in the substantial absence of actinic light for about 3 hours to about 12 hours.