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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12655473 B1

PDFFull Text
Date of Patent:
Jun. 16, 2026

Filed:

Oct. 23, 2023

Methods, compositions, and systems for mapping locations of single molecules in multi-dimensional space

Applicant:

Curio Bioscience, Inc., Palo Alto, CA (US);

Inventors:

Stephen P.A. Fodor, Palo Alto, CA (US);

Hei Mun Christina Fan, Palo Alto, CA (US);

Anaram Shahravan, San Jose, CA (US);

Christina Chang, Palo Alto, CA (US);

Jay Levine, San Leandro, CA (US);

Assignee:

Takara Bio USA, Inc., San Jose, CA (US);

Attorney:

Fenwick & West LLP

Primary Examiner:

Jeremy C Flinders

Int. Cl.
CPC ...
C12Q 1/6841 (2018.01); C12Q 1/6804 (2018.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6841 (2013.01); C12Q 1/6804 (2013.01); G01N 33/5308 (2013.01); G01N 33/54326 (2013.01); G01N 2458/10 (2013.01); G01N 2570/00 (2013.01);
Abstract

Systems, methods, and compositions for generating a high-resolution spatial map of a distribution of targets of a sample are described. Processes for generating the spatial map can include: receiving the sample at a substrate having a distribution of functionalized particles, each having a stochastic barcode sequence paired with a position on the substrate; promoting interactions between the distribution of targets of the sample and the distribution of functionalized particles upon transmitting heat to a surface of the substrate opposite the distribution of functionalized particles; applying a set of reactions to the sample at the substrate, obtaining a set of sequences of a population of molecules generated from the set of reactions, the set of sequences associated with the distribution of targets labeled using the stochastic barcode sequences of the distribution of functionalized particles, and returning a set of positions of the distribution of targets upon processing the set of sequences.

Find Patent Forward Citations

Fodor, Stephen P.A.. (2026). Methods, compositions, and systems for mapping locations of single molecules in multi-dimensional space (U.S. Patent No. 12655473). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12655473

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