The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2026
Filed:
Jul. 22, 2020
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Dieter Dorsch, Ober-Ramstadt, DE;
Andreas Blum, Bensheim, DE;
Hans-Peter Buchstaller, Griesheim, DE;
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 45/06 (2006.01); C07D 239/42 (2006.01); C07D 403/12 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 45/06 (2013.01); C07D 239/42 (2013.01); C07D 403/12 (2013.01); C07D 519/00 (2013.01);
Abstract
Compounds of the formula I are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer. Rdenotes H, Hal, CF, NO, A, [C(R)]N(R), [C(R)]Het, OR, O[C(R)]N(R), O[C(R)]S(O)R, O[C(R)]COOR, O[C(R)]COON(R), O[C(R)]Het, O[C(R)]N(R)Het, O[C(R)]Ph, or O[C(R)]Cyc. Rdenotes H or CH. Rdenotes H or A. V denotes H or Hal. X denotes O or N(R). Y denotes phenylene, pyridin-diyl, thiophen-diyl, 1,3-thiazol-diyl or pyrazol-diyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal and/or A. Z denotes CON(R), phenyl, Hetor —O-A.