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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12654154 B1

PDFFull Text
Date of Patent:
Jun. 16, 2026

Filed:

Mar. 17, 2023

Chiral bimetallic cooperative catalysis system containing chelating ligand and use thereof in asymmetric synthesis of bedaquiline

Applicant:

Shanghai Jiao Tong University, Shanghai, CN;

Inventors:

Wanbin Zhang, Shanghai, CN;

Feng Gao, Shanghai, CN;

Jing Li, Shanghai, CN;

Tanveer Ahmad, Shanghai, CN;

Yicong Luo, Shanghai, CN;

Zhenfeng Zhang, Shanghai, CN;

Assignee:

SHANGHAI JIAO TONG UNIVERSITY, Shanghai, CN;

Attorney:

Bayramoglu Law Offices LLC

Primary Examiner:

Latosha Hines

Int. Cl.
CPC ...
B01J 23/04 (2006.01); B01J 31/12 (2006.01); B01J 31/18 (2006.01); B01J 31/22 (2006.01);
U.S. Cl.
CPC ...
B01J 23/04 (2013.01); B01J 31/122 (2013.01); B01J 31/1805 (2013.01); B01J 31/2217 (2013.01); B01J 2231/34 (2013.01); B01J 2531/11 (2013.01);
Abstract

A chiral bimetallic cooperative catalysis system containing a chelating ligand and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, in the chiral bimetallic cooperative catalysis system, an equilibrium constant of a reaction is increased by the chelating ligand formed by an achiral secondary amine and chiral lithium aminoalcohol, thereby promoting an addition reaction between 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) to move forward. By means of the bimetallic cooperative catalysis system, the yield of the target product (1R,2S)-bedaquiline is obviously increased.

Find Patent Forward Citations

Zhang, Wanbin. (2026). Chiral bimetallic cooperative catalysis system containing chelating ligand and use thereof in asymmetric synthesis of bedaquiline (U.S. Patent No. 12654154). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12654154

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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