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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12653908 B1

PDFFull Text
Date of Patent:
Jun. 16, 2026

Filed:

Sep. 23, 2020

Method of transactivating a homologous gene of a gene of interest and an in vitro method of diagnosing a disease

Applicant:

Vigeneron Gmbh, Planegg, DE;

Inventors:

Stylianos Michalakis, Munich, DE;

Elvir Becirovic, Munich, DE;

Lisa Riedmayr, Munich, DE;

Victoria Splith, Munich, DE;

Sybille Böhm, Munich, DE;

Martin Biel, Starnberg, DE;

Assignee:

VeonGen Therapeutics GmbH, Planegg, DE;

Attorney:

Sheridan Ross P.C.

Primary Examiner:

Allison M Fox

Assistant Examiner:

Marisol Ann O'neill

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61P 27/02 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 48/0008 (2013.01); A61P 27/02 (2018.01); C12N 9/22 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); C12Q 1/6883 (2013.01); C12N 2310/20 (2017.05); C12N 2320/31 (2013.01); C12N 2750/14143 (2013.01);
Abstract

The present invention relates to a method of trans-activating a homologous gene of at least one gene of interest and optionally deactivation of at least one gene of interest, wherein the mRNA encoded by the at least one gene of interest comprises a mutation compared to a control, and wherein the method comprises the steps as described in the present application. The present invention further relates to an in vitro method of diagnosing a disease, wherein the method comprises the steps of: a) Inducing the expression of the mRNA encoded by at least one gene of interest in a cell or tissue sample obtained from a subject; b) isolating the mRNA of step a); c) analyzing the sequence of the isolated mRNA of step b) and d) thereby detecting a mutation of the mRNA compared to a control, which is indicative for the presence of the disease.

Find Patent Forward Citations

Michalakis, Stylianos. (2026). Method of transactivating a homologous gene of a gene of interest and an in vitro method of diagnosing a disease (U.S. Patent No. 12653908). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12653908

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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