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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12653893 B1

PDFFull Text
Date of Patent:
Jun. 16, 2026

Filed:

Feb. 14, 2024

Carbohydrate conjugated rna agents and process for their preparation

Applicant:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Jayaprakash K. Nair, Cambridge, MA (US);

Alexander V. Kel'in, Cambridge, MA (US);

Pachamuthu Kandasamy, Cambridge, MA (US);

Kallanthottathil G. Rajeev, Cambridge, MA (US);

Muthiah Manoharan, Cambridge, MA (US);

Assignee:

ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);

Attorney:

Blank Rome LLP

Primary Examiner:

Traviss C Mcintosh, III

Int. Cl.
CPC ...
C07H 1/00 (2006.01); A61K 31/7088 (2006.01); A61K 47/54 (2017.01); C07C 231/14 (2006.01); C07D 207/12 (2006.01); C07H 15/26 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/549 (2017.08); A61K 31/7088 (2013.01); C07C 231/14 (2013.01); C07D 207/12 (2013.01); C07H 1/00 (2013.01); C07H 15/26 (2013.01); C12N 15/113 (2013.01); C12N 2310/351 (2013.01); C12N 2320/32 (2013.01);
Abstract

This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

Find Patent Forward Citations

Nair, Jayaprakash. (2026). Carbohydrate conjugated rna agents and process for their preparation (U.S. Patent No. 12653893). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12653893

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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