The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 09, 2026

Filed:

Feb. 16, 2021
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Hakho Lee, Acton, MA (US);

Ralph Weissleder, Peabody, MA (US);

Jan Van Deun, Wilrijk, BE;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01D 15/18 (2006.01); B01D 15/34 (2006.01); B01D 15/36 (2006.01); B01D 21/26 (2006.01); B01D 61/14 (2006.01); B01D 69/02 (2006.01); B01D 71/56 (2006.01); G01N 1/40 (2006.01);
U.S. Cl.
CPC ...
B01D 15/1871 (2013.01); B01D 15/1885 (2013.01); B01D 15/34 (2013.01); B01D 15/362 (2013.01); B01D 21/262 (2013.01); B01D 61/145 (2013.01); B01D 69/02 (2013.01); B01D 71/56 (2013.01); G01N 1/405 (2013.01); B01D 2325/0283 (2022.08); B01D 2325/04 (2013.01); B01D 2325/34 (2013.01); G01N 2001/4011 (2013.01); G01N 2001/4088 (2013.01);
Abstract

The present disclosure provides, in some embodiments, devices, methods, and kits for purifying extracellular vesicles (EVs) using size exclusion chromatography in tandem with cation exchange chromatography, which can be referred to as dual-mode chromatography (DMC).


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