The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2026
Filed:
Sep. 21, 2021
Applicant:
Treefrog Therapeutics, Pessac, FR;
Inventors:
Maxime Feyeux, Talence, FR;
Andrea Leonard, Pessac, FR;
Assignee:
TREEFROG THERAPEUTICS, Pessac, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
G01N 33/5061 (2013.01); C12N 5/0657 (2013.01); C12N 2501/415 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01); C12N 2533/74 (2013.01);
Abstract
The invention relates to cellular microcompartments, each microcompartment successively comprising the following layers, which are organised around at least one lumen: —at least one inner layer of human cells undergoing cardiac differentiation, expressing at least one gene chosen from PDGFRα, MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1 and TBX5, —at least one intermediate layer of isotonic aqueous solution, and—at least one outer hydrogel layer. The invention also relates to the cardiac tissues obtained from said microcompartments and the use thereof, particularly in the treatment of heart disease.