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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12644131 B1

PDFFull Text
Date of Patent:
Jun. 02, 2026

Filed:

Apr. 10, 2020

Virus compositions with enhanced specificity in the brain

Applicant:

California Institute of Technology, Pasadena, CA (US);

Inventors:

Viviana Gradinaru, Pasadena, CA (US);

Sripriya Ravindra Kumar, Chennai, IN;

Benjamin Deverman, Boston, MA (US);

Assignee:

California Institute of Technology, Pasadena, CA (US);

Attorneys:

Brown Rudnick LLP

Adam M. Schoen

Primary Examiner:

Tekchand Saidha

Assistant Examiner:

Mohammad Y Meah

Int. Cl.
CPC ...
C12N 15/80 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01); C12N 2750/14171 (2013.01);
Abstract

Provided are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell-types, for e.g., the brain and the liver. Therapeutic and biomedical research applications of the rAAVs are also described, including without limitation methods of discovering rAAVs using a multiplexed Cre recombination-based AAV targeted evolution (M-CREATE) method, and methods of treating various diseases and conditions by rAAV-mediated transgene therapy.

Find Patent Forward Citations

Gradinaru, Viviana. (2026). Virus compositions with enhanced specificity in the brain (U.S. Patent No. 12644131). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12644131

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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