The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 02, 2026

Filed:

Mar. 04, 2025
Applicant:

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

Nancy Allbritton, Chapel Hill, NC (US);

Yuli Wang, Cary, NC (US);

Hennayaka Mudiyanselage Dulan Gunasekara, Carrboro, NC (US);

Christopher Sims, Chapel Hill, NC (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/12 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12M 25/14 (2013.01); C12M 23/20 (2013.01); C12M 35/08 (2013.01); C12N 5/0062 (2013.01); C12N 5/0679 (2013.01); G01N 33/5014 (2013.01); C12N 2513/00 (2013.01); C12N 2533/54 (2013.01); C12N 2537/10 (2013.01);
Abstract

The present invention is directed to a method of making a live cell construct or a support, comprising: (a) providing a non-cellular organic polymer support having a top surface, a bottom surface, and an intermediate portion there between, and (b) contacting a cross-linking agent to one surface of said support for a time sufficient to generate a gradient of cross-linking of said polymer in said intermediate portion. Also provided are live cell constructs, supports, and methods of use of the supports and live cell constructs.


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