The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2026
Filed:
Mar. 30, 2022
Applicant:
Virginia Commonwealth University, Richmond, VA (US);
Inventor:
Yan Zhang, Glen Allen, VA (US);
Assignee:
Virginia Commonwealth University, Richmond, VA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01); A61K 9/19 (2006.01); A61K 31/485 (2006.01); C07D 489/08 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07D 489/08 (2013.01); A61K 9/19 (2013.01); A61K 31/485 (2013.01); A61K 47/55 (2017.08); G01N 33/6863 (2013.01);
Abstract
Bivalent ligands which bind to MOR-CCR5 heterodimers are provided. The bivalent ligands comprise two discrete pharmacophores, naltrexone and maraviroc, linked by a spacer and bind to MOR-CCR5 heterodimers, e.g. at the surface of a cell. The bivalent ligands are useful in assays to detect MOR-CCR5 heterodimers, as therapeutic agents to prevent and/or treat diseases characterized by the presence of MOR-CCR5 heterodimers.
Zhang, Yan. (2026). Bivalent ligands to understand dimerization of the mu opioid receptor and the chemokine receptor ccr5 in neurological disorders (U.S. Patent No. 12643909). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12643909
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile