The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2026
Filed:
May. 14, 2021
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang, CN;
Guorui Mi, Shijiazhuang, CN;
Yan Zhang, Shijiazhuang, CN;
Chunhua Jiang, Shijiazhuang, CN;
Yanxia Xu, Shijiazhuang, CN;
Lixue Fan, Shijiazhuang, CN;
Xuejiao Zhang, Shijiazhuang, CN;
Yanan Qin, Shijiazhuang, CN;
CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD, Shijiazhuang, CN;
Abstract
A compound of formula (I) or a tautomer, a stereoisomer, a solvate, a nitrogen oxide, a prodrug, an isotope derivative or a pharmaceutically acceptable salt thereof exhibit kinase inhibitory activity against a variety of kinases (such as TRK, ALK and ROS1) and mutants thereof, in particular TRK and a mutant form thereof. An in vitro cell inhibitory activity test and an in vivo anti-tumor model test show that the compounds have a strong inhibitory effect on a variety of cells containing TRK mutations and tumors, have a good safety, and have a good clinical value as drugs.