The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2026
Filed:
Sep. 29, 2021
Applicant:
Beigene, Ltd., Grand Cayman, KY;
Inventors:
Bailin Lei, Beijing, CN;
Huaqing Liu, Beijing, CN;
Songzhe Han, Beijing, CN;
Zhiwei Wang, Beijing, CN;
Assignee:
BeOne Medicines I GmbH, Basel, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01);
Abstract
Disclosed herein are bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation of mutant EGFR kinase, and methods of preparation and uses thereof.