The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 02, 2026

Filed:

Sep. 28, 2021
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Adam R. Abate, San Francisco, CA (US);

Jesse Qiuxu Zhang, San Francisco, CA (US);

Leqian Liu, San Francisco, CA (US);

Cyrille L. Delley, San Francisco, CA (US);

Russell Cole, San Francisco, CA (US);

Christian Siltanen, San Francisco, CA (US);

Ata Dolatmoradi, San Jose, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01L 3/02 (2006.01);
U.S. Cl.
CPC ...
B01L 3/0268 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0439 (2013.01);
Abstract

Provided is a method of generating droplets that includes aspirating a first liquid into a tube, positioning the tube over a receiving liquid, and ejecting the first liquid to generate a plurality of droplets that contact the receiving liquid and remain discrete even after contacting the receiving liquid. Whereas many other droplet generators require complex microfluidics, the present methods allow generation of droplets without the need for microfluidics. The methods can be performed with existing commercially available macro-fluidic liquid handling devices. The methods can be used for digital PCR, digital MDA, enzyme screening, single cell analysis, and other applications involving droplets.


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