The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2026
Filed:
Nov. 04, 2016
Applicant:
Fate Therapeutics, Inc., San Diego, CA (US);
Inventors:
Bahram Valamehr, San Diego, CA (US);
Ramzey Abujarour, San Diego, CA (US);
Tom Tong Lee, San Diego, CA (US);
Weijie Lan, San Diego, CA (US);
Raedun Clarke, San Diego, CA (US);
Ryan Bjordahl, San Diego, CA (US);
Assignee:
Fate Therapeutics, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); A61K 40/11 (2025.01); C12N 5/0783 (2010.01); C12N 9/50 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 40/11 (2025.01); C12N 5/0636 (2013.01); C12N 5/0696 (2013.01); C12N 9/50 (2013.01); C12N 15/86 (2013.01); C12Y 304/22062 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01); C12N 2830/00 (2013.01);
Abstract
Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites. Also provided are cell populations or clonal cell lines derived from genome-engineered iPSCs, which comprise targeted integration of one or more exogenous polynucleotides, and/or in/dels in one or more selected endogenous genes.