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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12637471 B1

PDFFull Text
Date of Patent:
May. 26, 2026

Filed:

May. 05, 2022

Heterocyclic compounds, compositions, methods of preparation and uses thereof

Applicant:

Organon R&d Finland Ltd, Turku, FI;

Inventors:

Tero Linnanen, Naantali, FI;

Leena Hirvelä, Turku, FI;

Kaisa Illikainen, Turku, FI;

Marjo Hakola, Turku, FI;

Sanna Niinivehmas, Littoinen, FI;

Olli Pentikäinen, Lieto, FI;

Camilla Stjernschantz, Turku, FI;

Assignee:

ORGANON R&D FINLAND LTD., Turku, FI;

Attorneys:

Barnes & Thornburg LLP

Ryan L. Marshall

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Alexander K. Showalter

Int. Cl.
CPC ...
C07D 211/70 (2006.01); A61K 31/4535 (2006.01); A61K 31/4545 (2006.01); A61K 31/497 (2006.01); A61K 31/4985 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); C07D 211/72 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 409/06 (2006.01); C07D 409/14 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); C07D 498/18 (2006.01); C07D 513/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4535 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/4985 (2013.01); C07D 211/70 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 409/06 (2013.01); C07D 409/14 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C07D 498/18 (2013.01);
Abstract

The present invention relates to compounds of formula (I) to salts, solvates and solvates of salts thereof, and to pharmaceutical compositions comprising these compounds as active ingredients. The invention further relates to their use as aldo-keto reductase family 1 C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) and prostaglandin (PG) F2α synthase, inhibitors. The invention further relates to methods for their preparation, and to uses of said compounds.

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