The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2026
Filed:
Feb. 23, 2021
Ocumension Therapeutics (Suzhou) Co., Ltd., Suzhou city, CN;
Wenyuan Qian, Shanghai, CN;
Hongjian Wang, Shanghai, CN;
Liang Tan, Shanghai, CN;
Shuhui Chen, Shanghai, CN;
OCUMENSION THERAPEUTICS (SUZHOU) CO., LTD., Suzhou City, CN;
Abstract
The present disclosure relates to a class of spleen tyrosine kinase (Syk) and vascular endothelial growth factor receptor 2 (VEGFR2) dual inhibitors. Specifically, it discloses a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the compound, a method of inhibiting spleen tyrosine kinase (Syk) and vascular endothelial growth factor 2 in a subject, and a method of treating allergic, autoimmune and inflammatory diseases. The compound exhibits good Syk and VEGFR2 dual inhibitory activity as well as excellent targeting specificity, with no off-target selectivity issues. Additionally, the compound of the present disclosure has a high eye-to-blood ratio and is suitable for ocular administration.