The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2026
Filed:
Dec. 12, 2019
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Miles A. Miller, Medford, MA (US);
Ralph Weissleder, Peabody, MA (US);
Hannes Mikula, Pixendorf, AT;
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/60 (2017.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/60 (2017.08); A61K 47/542 (2017.08); A61K 47/6937 (2017.08); A61P 35/00 (2018.01);
Abstract
Provided is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein L, L, L, n, m, p, X, T, TR, and D are as described herein, that is a prodrug that can, for example, be encapsulated in a particle, administered to a subject, and its drug payload released by means of an uncaging reaction. Methods of using these compounds to treat diseases advantageously treatable by drug D are also described.