The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2026
Filed:
Sep. 09, 2020
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
North Carolina State University, Raleigh, NC (US);
Paul Alexander Dayton, Carrboro, NC (US);
Jinwook Kim, Chapel Hill, NC (US);
Xiaoning Jiang, Cary, NC (US);
Zhen Xu, Ann Arbor, MI (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
North Carolina State University, Raleigh, NC (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Abstract
A method for using metastable perfluorocarbon nanodroplets for ultrasonic lysis of blood clots includes administering metastable perfluorocarbon nanodroplets into a blood vessel that includes or that leads to a blood vessel that includes a blood clot, the metastable perfluorocarbon nanodroplets each have a liquid core comprising a perfluorocarbon material that has a boiling point below 25° C. at atmospheric pressure and that remains stable in liquid form at 25° C. at atmospheric pressure. The method further includes applying ultrasound energy to the perfluorocarbon nanodroplets within or surrounding the blood clot, causing the perfluorocarbon nanodroplets to vaporize and convert to bubbles, which cavitate and lyse the blood clot.