The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 19, 2026
Filed:
Jun. 21, 2022
Indole-substituted quinolines and their combination with plk1 inhibitors for the treatment of cancer
Applicant:
University of Kentucky Research Foundation, Lexington, KY (US);
Inventors:
Chunming Liu, Lexington, KY (US);
David S Watt, Lexington, KY (US);
Assignee:
University of Kentucky Research Foundation, Lexington, KY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07D 401/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 401/04 (2013.01);
Abstract
Indole-substituted quinolines (ISQs) are provided which may include a variety of substituted piperidines. Methods for treating cancers, including c-MYC-driven cancers, are described including administering the ISQs to a subject in need thereof. The compounds may be administered in combination with a polo-like kinase-1 (Plk1) inhibitor. The Plk1 and the compound may be administered in synergistically effective amounts.