The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2026

Filed:

Nov. 02, 2020
Applicant:

Albert Einstein College of Medicine, Bronx, NY (US);

Inventors:

Victor L. Schuster, New York, NY (US);

William Greenlee, Bronx, NY (US);

Evripidis Gavathiotis, Roslyn, NY (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/42 (2006.01); C07D 241/20 (2006.01); C07D 263/48 (2006.01); C07D 271/113 (2006.01); C07D 277/28 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 239/42 (2013.01); C07D 241/20 (2013.01); C07D 263/48 (2013.01); C07D 271/113 (2013.01); C07D 277/28 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

The disclosure provides compounds of Formula 1, and the pharmaceutically acceptable salts thereof. The variables in Formula 1, e.g. X-X, A, A, and R-Rare described herein. Such compounds are useful as prostaglandin transport (PGT) inhibitors. The disclosure further includes pharmaceutical compositions comprising a compound of Formula 1 or salt thereof and methods of using compounds of Formula 1 and salts thereof to treat diseases and disorders mediated, at least in part, by prostaglandin levels or cyclooxygenase activity. Such diseases and disorders include painful and inflammatory conditions.


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