The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2026

Filed:

Feb. 24, 2023
Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Kyungyong Choi, Cambridge, MA (US);

Jongyoon Han, Bedford, MA (US);

Stacy L. Springs, Medford, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); B01L 3/00 (2006.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); C07F 5/02 (2006.01); C09B 57/00 (2006.01); C09K 11/06 (2006.01); G01N 1/30 (2006.01); G01N 15/10 (2024.01); G01N 15/1429 (2024.01); G01N 27/626 (2021.01); G01N 31/22 (2006.01); G01N 33/483 (2006.01); G01N 33/543 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502753 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0883 (2013.01);
Abstract

A spiral inertial microfluidics device has been designed for use as a microfluidic sorting device. The device includes a spiral microchannel in which particles or cells of different sizes go through regions having different magnitudes of inertial and/or drag forces and equilibrate at different lateral positions in the microchannel so that those particles or cells of different sizes are separated. Using different focusing characteristics of larger versus smaller particles/cells in the spiral microchannel, adventitious agents (AAs) such as bacteria, virus, mycoplasma, etc. can be selectively removed from cells such as those producing therapeutic enzymes or monoclonal antibodies or those comprising the product itself.


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