The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2026

Filed:

Jun. 29, 2018
Applicants:

Kolon Life Science, Inc., Seoul, KR;

Kolon Tissuegene, Inc., Rockville, MD (US);

Inventors:

Sang Eun Noh, Incheon, KR;

Soon Dong Lee, Gyeonggi-do, KR;

Hyeon Youl Lee, Gyeonggi-do, KR;

Seung Taeh Hwang, Incheon, KR;

Ha Eun Kim, Seoul, KR;

Min Ho Choi, Seoul, KR;

Assignees:

KOLON LIFE SCIENCE, INC., Seoul, KR;

KOLON TISSUEGENE, INC., Rockville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/32 (2015.01); A61P 19/02 (2006.01); C12N 5/071 (2010.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 35/32 (2013.01); A61P 19/02 (2018.01); C12N 5/0655 (2013.01); C12N 5/0697 (2013.01); C12N 2501/15 (2013.01); C12N 2529/00 (2013.01);
Abstract

A pharmaceutical composition for prevention or treatment of osteoarthritis according to an embodiment of the present disclosure includes cells or cell groups having a specific size or less. Mixed cells, which are selected to a specific size or less as an active ingredient of the present invention, of transformed mammalian cells with TGF-β and untransformed mammalian cells minimize aggregation between chondrocytes and have beneficial therapeutic effects. In addition, when administering the selected mixed cells having the specific size or less to a patient, patient compliance may be improved, and it is easy to manage quality in therapeutic agent manufacturing facilities or hospitals.


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