The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 19, 2026

Filed:

Feb. 02, 2021
Applicants:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

The Walter and Eliza Hall Institute of Medical Research, Parkville, AU;

Msd R&d (China) Co., Ltd., Shanghai, CN;

Inventors:

Manuel De Lera Ruiz, Perkasie, PA (US);

Paola Favuzza, Victoria, AU;

Zhuyan Guo, Scotch Plains, NJ (US);

Bin Hu, Shanghai, CN;

Michael J. Kelly, III, Paoli, PA (US);

Zhiyu Lei, Shanghai, CN;

John A. Mccauley, Maple Glen, PA (US);

David B. Olsen, Lansdale, PA (US);

Brad Sleebs, Victoria, AU;

Tony Triglia, Victoria, AU;

Dongmei Zhan, Shanghai, CN;

Lianyun Zhao, Shanghai, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61K 31/529 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); A61P 33/06 (2006.01); C07D 233/88 (2006.01); C07D 401/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 417/14 (2006.01); C07D 491/18 (2006.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A61K 31/529 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 33/06 (2018.01); C07D 233/88 (2013.01); C07D 401/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 417/14 (2013.01); C07D 491/18 (2013.01);
Abstract

Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Also provided are uses of the compounds of Formula (I), as defined herein, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.


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