The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2026

Filed:

Mar. 22, 2023
Applicant:

Genesis Technologies Limited, St. Michael, BB;

Inventors:

Jan-Eric Ahlfors, Laval, CA;

Rouwayda El-Ayoubi, Laval, CA;

Assignee:

Genesis Technologies Limited, St. Michael, BB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0775 (2010.01); A61K 35/30 (2015.01); C12N 5/074 (2010.01); C12N 5/077 (2010.01); C12N 5/0789 (2010.01); C12N 5/079 (2010.01); C12N 5/0793 (2010.01); C12N 5/0797 (2010.01); A61K 35/545 (2015.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0662 (2013.01); A61K 35/30 (2013.01); C12N 5/0618 (2013.01); C12N 5/0619 (2013.01); C12N 5/0623 (2013.01); C12N 5/0647 (2013.01); C12N 5/0656 (2013.01); C12N 5/0657 (2013.01); C12N 5/0667 (2013.01); C12N 5/0668 (2013.01); C12N 5/0696 (2013.01); A61K 35/545 (2013.01); C12N 5/0676 (2013.01); C12N 2500/25 (2013.01); C12N 2501/06 (2013.01); C12N 2501/065 (2013.01); C12N 2501/105 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/13 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/395 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/604 (2013.01); C12N 2501/727 (2013.01); C12N 2501/998 (2013.01); C12N 2506/094 (2013.01); C12N 2506/11 (2013.01); C12N 2506/1307 (2013.01); C12N 2506/1346 (2013.01); C12N 2506/1384 (2013.01); C12N 2510/00 (2013.01); C12N 2513/00 (2013.01);
Abstract

A method of obtaining a pluripotent-like multipotent cell, including providing a cell of a first type which is not a pluripotent-like multipotent cell; contacting the cell of a first type with an agent capable of remodeling the chromatin and/or DNA of the cell; transiently increasing expression of at least one pluripotent gene regulator in the cell of a first type, to a level at which the at least one pluripotent gene regulator is capable of driving transformation of the cell of a first type into the pluripotent-like multipotent cell; and placing or maintaining the cell in a differentiation medium and maintaining intracellular levels of the at least one pluripotent gene regulator for a sufficient period of time to allow a stable pluripotent-like multipotent cell to be obtained; wherein the pluripotent-like multipotent cell so obtained does not exhibit teratoma formation in vivo.


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