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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12624339 B1

PDFFull Text
Date of Patent:
May. 12, 2026

Filed:

Jun. 04, 2025

Brain organoid containing optic vesicles generated based on h9 induction and eye-brain fusion culture method

Applicant:

Tianjin University, Tianjin, CN;

Inventors:

Liqun Chen, Tianjin, CN;

Rui Hu, Tianjin, CN;

Dong Ming, Tianjin, CN;

Assignee:

Tianjin University, Tianjin, CN;

Attorney:

COOPER LEGAL GROUP LLC

Primary Examiner:

Peter Paras, Jr

Assistant Examiner:

Constantina E Stavrou

Int. Cl.
CPC ...
C12N 5/079 (2010.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0618 (2013.01); C12N 5/0062 (2013.01); C12N 2500/38 (2013.01); C12N 2501/13 (2013.01); C12N 2501/155 (2013.01); C12N 2506/02 (2013.01); C12N 2509/00 (2013.01); C12N 2513/00 (2013.01); C12N 2533/90 (2013.01);
Abstract

A brain organoid containing optic vesicles generated based on H9 induction and an eye-brain fusion culture method thereof are provided. H9 embryonic stem cell induction is used to generate a brain organoid containing optic vesicles with primitive visual field. Based on an established optic vesicle brain organoid culture system, microscopic imaging is combined with specific marker antibodies related to early retinal development and photoreceptor cell maturation to structurally and functionally identify the brain organoid containing optic vesicles.

Find Patent Forward Citations

Chen, Liqun. (2026). Brain organoid containing optic vesicles generated based on h9 induction and eye-brain fusion culture method (U.S. Patent No. 12624339). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12624339

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