The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2026
Filed:
May. 19, 2020
Novartis Ag, Basel, CH;
Brian Walter Granda, Salisbury, MA (US);
John Blankenship, Acton, MA (US);
Aida Abujoub, Winchester, MA (US);
Tony Fleming, Stow, MA (US);
Lu Huang, West Roxbury, MA (US);
Connie Hong, Somerville, MA (US);
Brian Holmberg, Somerville, MA (US);
Haihui Lu, Winchester, MA (US);
NOVARTIS AG, Basel, CH;
Abstract
The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates. The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.