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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12624044 B1

PDFFull Text
Date of Patent:
May. 12, 2026

Filed:

Jun. 10, 2020

Smarca degraders and uses thereof

Applicant:

Kymera Therapeutics, Inc., Watertown, MA (US);

Inventors:

Nan Ji, Arlington, MA (US);

Yi Zhang, Belmont, MA (US);

Matthew M. Weiss, Boston, MA (US);

Paul R. Fleming, Lexington, MA (US);

Assignee:

Kymera Therapeutics, Inc., Watertown, MA (US);

Attorneys:

COOLEY LLP

John P. Rearick

Todd K. Macklin

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

Alison Azar Salamatian

Int. Cl.
CPC ...
A61P 35/00 (2006.01); C07D 237/20 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/10 (2006.01); C07D 487/08 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 487/08 (2013.01); C07D 237/20 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01);
Abstract

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiquitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.

Find Patent Forward Citations

Ji, Nan. (2026). Smarca degraders and uses thereof (U.S. Patent No. 12624044). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12624044

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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