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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12624034 B1

PDFFull Text
Date of Patent:
May. 12, 2026

Filed:

Jun. 02, 2025

Non-covalent modifiers of akt1 and uses thereof

Applicant:

Terremoto Biosciences, Inc., South San Francisco, CA (US);

Inventors:

Hang Chu, San Mateo, CA (US);

Kin S. Yang, San Mateo, CA (US);

Solomon H. Reisberg, Contra Costa, CA (US);

Adam Zajdlik, San Francisco, CA (US);

Jordan D. Carelli, San Francisco, CA (US);

Brian P. Bestvater, South San Francisco, CA (US);

Timothy R. Hansen, San Francisco, CA (US);

Peter A. Thompson, Kirkland, WA (US);

Assignee:

TERREMOTO BIOSCIENCES, INC., South San Francisco, CA (US);

Attorney:

WILSON SONSINI GOODRICH & ROSATI

Primary Examiner:

Kamal A Saeed

Assistant Examiner:

Jalisa Holmes Ferguson

Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/4725 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61P 35/00 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/4725 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/5025 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61P 35/00 (2018.01); C07D 519/00 (2013.01);
Abstract

Provided herein are non-covalent modifiers of AKT1 of Formula (I), (II), (II-A), (III), (III-A), (III-B), (IV), (IV-A), (IV-B), (V), (V-A), (V-B), (VI), (VI-A), or (VI-B), and pharmaceutical compositions thereof. In some embodiments, the present disclosure provides methods of modulating wild-type AKT1 using a compound or salt of Formula (I), (II), (II-A), (III), (III-A), (III-B), (IV), (IV-A), (IV-B), (V), (V-A), (V-B), (VI), (VI-A), or (VI-B), and pharmaceutical compositions thereof.

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