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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12624032 B1

PDFFull Text
Date of Patent:
May. 12, 2026

Filed:

Feb. 20, 2024

Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases

Applicants:

University of Houston System, Houston, TX (US);

Trustees of Tufts College, Medford, MA (US);

Inventors:

Gregory Cuny, Houston, TX (US);

Sameer Nikhar, Houston, TX (US);

Alexei Degterev, Brookline, MA (US);

Assignees:

UNIVERSITY OF HOUSTON SYSTEM, Houston, TX (US);

TRUSTEES OF TUFTS COLLEGE, Medford, MA (US);

Attorney:

Jackson Walker LLP

Primary Examiner:

Brenda L Coleman

Int. Cl.
CPC ...
C07D 239/84 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61K 31/517 (2006.01); A61P 19/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01);
Abstract

Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.

Find Patent Forward Citations

Cuny, Gregory. (2026). Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases (U.S. Patent No. 12624032). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12624032

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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