The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2026
Filed:
Apr. 02, 2021
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Simon Giroux, Cambridge, MA (US);
Philippe Marcel Nuhant, Dorchester, MA (US);
Upul Keerthi Bandarage, Lexington, MA (US);
Pedro Manuel Garcia Barrantes, Melrose, MA (US);
Yusheng Liao, Lexington, MA (US);
Zachary Gale-Day, Brookline, MA (US);
Wenxin Gu, Concord, MA (US);
Alexander S. Karns, Boston, MA (US);
Hu Zhang, Newton, MA (US);
Emily Elizabeth Allen, Boston, MA (US);
Jinwang Xu, Framingham, MA (US);
Michael Paul Deninno, Gales Ferry, CT (US);
Qing Tang, Boxborough, MA (US);
Diane Marie Boucher, Beverly, MA (US);
Lev T.D. Fanning, San Marcos, CA (US);
Amy B. Hall, Wellesley Hills, MA (US);
Dennis James Hurley, San Marcos, CA (US);
Mac Arthur Johnson, Jr., Derry, NH (US);
John Patrick Maxwell, Hingham, MA (US);
Rebecca Jane Swett, Somerville, MA (US);
Timothy Lewis Tapley, Cardiff, CA (US);
Stephen A. Thomson, Durham, NC (US);
Veronique Damagnez, Framingham, MA (US);
Kevin Michael Cottrell, Cambridge, MA (US);
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Abstract
1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).