The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 12, 2026
Filed:
Feb. 04, 2021
Applicant:
Leadingtac Pharmaceutical (Shaoxing) Co., Ltd., Shaoxing, CN;
Inventors:
Yan Feng, Shanghai, CN;
Shiqiang Li, Shanghai, CN;
Assignee:
LEADINGTAC PHARMACEUTICAL (SHAOXING) CO., LTD., Zhejiang, CN;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 471/10 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 471/10 (2013.01);
Abstract
A class of indazole derivatives targeting an IRAK4 kinase protein for degradation, and a preparation method therefor and the use thereof are provided. In particular, the compound of formula I, a preparation method therefor, and a pharmaceutical composition thereof and the use thereof are presented. The compound can significantly degrade the IRAK4 kinase protein in cells and can be used as a drug for the treatment and/or prevention of related diseases or conditions mediated by the IRAK4, such as cancers, immune diseases, and inflammatory diseases.